Key West to Port Saint Lucie: Road Trip Guide & Distance

How far is Key West from Port Saint Lucie?

The distance from Key West to Port Saint Lucie is 209 miles (336.4 km) as the crow flies. Port Saint Lucie is located NNE of Key West. By car, the driving distance is approximately 261.3 miles, taking about 5h 15min. A direct flight would take roughly 55min. Both are located in United States.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Key West and Port Saint Lucie. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.