Key Largo to Sanibel Island: Road Trip Guide & Distance

How far is Key Largo from Sanibel Island?

The distance from Key Largo to Sanibel Island is 135.9 miles (218.7 km) as the crow flies. Sanibel Island is located NW of Key Largo. By car, the driving distance is approximately 169.9 miles, taking about 3h 25min. A direct flight would take roughly 46min. Both are located in United States.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. Given the short distance, driving or taking a train is often faster and more convenient than dealing with airport security and flight boarding times.

Coordinates come from public place data for Key Largo and Sanibel Island. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.