Jacksonville, North Carolina to Knoxville: Road Trip Guide & Distance

How far is Jacksonville, North Carolina from Knoxville?

The distance from Jacksonville, North Carolina to Knoxville is 375.1 miles (603.6 km) as the crow flies. Knoxville is located WNW of Jacksonville, North Carolina. By car, the driving distance is approximately 450.1 miles, taking about 9h 3min. A direct flight would take roughly 1h 15min. Both are located in United States — Jacksonville, North Carolina in North Carolina and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Jacksonville, North Carolina and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.