Iowa City to O'Fallon, Missouri: Road Trip Guide & Distance

How far is Iowa City from O'Fallon, Missouri?

The distance from Iowa City to O'Fallon, Missouri is 201.8 miles (324.7 km) as the crow flies. O'Fallon, Missouri is located SSE of Iowa City. By car, the driving distance is approximately 252.2 miles, taking about 5h 4min. A direct flight would take roughly 54min. Both are located in United States — Iowa City in Iowa and O'Fallon, Missouri in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Iowa City and O'Fallon, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.