Indianapolis to Tupelo: Road Trip Guide & Distance

How far is Indianapolis from Tupelo?

The distance from Indianapolis to Tupelo is 405.8 miles (653 km) as the crow flies. Tupelo is located SSW of Indianapolis. By car, the driving distance is approximately 499.5 miles, taking about 9h 34min. A direct flight would take roughly 1h 19min. Both are located in United States — Indianapolis in Indiana and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Indianapolis and Tupelo. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.