Indianapolis to Kirksville: Road Trip Guide & Distance

How far is Indianapolis from Kirksville?

The distance from Indianapolis to Kirksville is 341.4 miles (549.4 km) as the crow flies. Kirksville is located W of Indianapolis. By car, the driving distance is approximately 402.2 miles, taking about 7h 36min. A direct flight would take roughly 1h 11min. Both are located in United States — Indianapolis in Indiana and Kirksville in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Indianapolis and Kirksville. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.