Hilton Head Island to Knoxville: Road Trip Guide & Distance

How far is Hilton Head Island from Knoxville?

The distance from Hilton Head Island to Knoxville is 315.8 miles (508.3 km) as the crow flies. Knoxville is located NW of Hilton Head Island. By car, the driving distance is approximately 379 miles, taking about 7h 38min. A direct flight would take roughly 1h 8min. Both are located in United States — Hilton Head Island in South Carolina and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Hilton Head Island and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.