Hamilton, Ohio to Knoxville: Road Trip Guide & Distance

How far is Hamilton, Ohio from Knoxville?

The distance from Hamilton, Ohio to Knoxville is 240.2 miles (386.5 km) as the crow flies. Knoxville is located S of Hamilton, Ohio. By car, the driving distance is approximately 300.2 miles, taking about 6h 2min. A direct flight would take roughly 59min. Both are located in United States — Hamilton, Ohio in Ohio and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee.

Coordinates come from public place data for Hamilton, Ohio and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.