Greenville, South Carolina to Tuscaloosa: Road Trip Guide & Distance

How far is Greenville, South Carolina from Tuscaloosa?

The distance from Greenville, South Carolina to Tuscaloosa is 317.3 miles (510.6 km) as the crow flies. Tuscaloosa is located WSW of Greenville, South Carolina. By car, the driving distance is approximately 380.7 miles, taking about 7h 40min. A direct flight would take roughly 1h 8min. Both are located in United States — Greenville, South Carolina in South Carolina and Tuscaloosa in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Greenville, South Carolina and Tuscaloosa. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.