Greenville, Mississippi to St. Louis: Road Trip Guide & Distance

How far is Greenville, Mississippi from St. Louis?

The distance from Greenville, Mississippi to St. Louis is 363.7 miles (585.3 km) as the crow flies. St. Louis is located N of Greenville, Mississippi. By car, the driving distance is approximately 436.5 miles, taking about 8h 47min. A direct flight would take roughly 1h 14min. Both are located in United States — Greenville, Mississippi in Mississippi and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading North for this distance usually means noticeable weather changes. Make sure to check the forecast for your destination before hitting the road.

Coordinates come from public place data for Greenville, Mississippi and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.