Greenville, Mississippi to Sikeston: Road Trip Guide & Distance

How far is Greenville, Mississippi from Sikeston?

The distance from Greenville, Mississippi to Sikeston is 253.6 miles (408.1 km) as the crow flies. Sikeston is located NNE of Greenville, Mississippi. By car, the driving distance is approximately 317 miles, taking about 6h 23min. A direct flight would take roughly 1h 1min. Both are located in United States — Greenville, Mississippi in Mississippi and Sikeston in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Greenville, Mississippi and Sikeston. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.