Greenville, Mississippi to Panama City Beach: Road Trip Guide & Distance

How far is Greenville, Mississippi from Panama City Beach?

The distance from Greenville, Mississippi to Panama City Beach is 380.8 miles (612.9 km) as the crow flies. Panama City Beach is located SE of Greenville, Mississippi. By car, the driving distance is approximately 457 miles, taking about 9h 12min. A direct flight would take roughly 1h 16min. Both are located in United States — Greenville, Mississippi in Mississippi and Panama City Beach in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Greenville, Mississippi and Panama City Beach. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.