Greenville, Mississippi to Kirksville: Road Trip Guide & Distance

How far is Greenville, Mississippi from Kirksville?

The distance from Greenville, Mississippi to Kirksville is 476.3 miles (766.6 km) as the crow flies. Kirksville is located N of Greenville, Mississippi. By car, the driving distance is approximately 571.6 miles, taking about 11h 30min. A direct flight would take roughly 1h 27min. Both are located in United States — Greenville, Mississippi in Mississippi and Kirksville in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading North for this distance usually means noticeable weather changes. Make sure to check the forecast for your destination before hitting the road.

Coordinates come from public place data for Greenville, Mississippi and Kirksville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.