Greensboro to Sikeston: Road Trip Guide & Distance

How far is Greensboro from Sikeston?

The distance from Greensboro to Sikeston is 546.8 miles (880 km) as the crow flies. Sikeston is located W of Greensboro. By car, the driving distance is approximately 656.2 miles, taking about 13h 12min. A direct flight would take roughly 1h 36min. Both are located in United States — Greensboro in North Carolina and Sikeston in Missouri.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Greensboro and Sikeston. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.