Great Smoky Mountains to St. Louis: Road Trip Guide & Distance

How far is Great Smoky Mountains from St. Louis?

The distance from Great Smoky Mountains to St. Louis is 424.1 miles (682.6 km) as the crow flies. St. Louis is located WNW of Great Smoky Mountains. By car, the driving distance is approximately 509 miles, taking about 10h 14min. A direct flight would take roughly 1h 21min. Both are located in United States — Great Smoky Mountains in Tennessee and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Great Smoky Mountains and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.