Gainesville, Florida to Winston-Salem: Road Trip Guide & Distance

How far is Gainesville, Florida from Winston-Salem?

The distance from Gainesville, Florida to Winston-Salem is 461.6 miles (742.8 km) as the crow flies. Winston-Salem is located NNE of Gainesville, Florida. By car, the driving distance is approximately 553.9 miles, taking about 11h 9min. A direct flight would take roughly 1h 26min. Both are located in United States — Gainesville, Florida in Florida and Winston-Salem in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Gainesville, Florida and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.