Gainesville, Florida to St. Louis: Road Trip Guide & Distance

How far is Gainesville, Florida from St. Louis?

The distance from Gainesville, Florida to St. Louis is 765.7 miles (1232.3 km) as the crow flies. St. Louis is located NW of Gainesville, Florida. By car, the driving distance is approximately 918.9 miles, taking about 18h 29min. A direct flight would take roughly 2h 2min. Both are located in United States — Gainesville, Florida in Florida and St. Louis in Missouri.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Gainesville, Florida and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.