Gainesville, Florida to Key West: Road Trip Guide & Distance

How far is Gainesville, Florida from Key West?

The distance from Gainesville, Florida to Key West is 353.7 miles (569.3 km) as the crow flies. Key West is located S of Gainesville, Florida. By car, the driving distance is approximately 424.5 miles, taking about 8h 32min. A direct flight would take roughly 1h 13min. Both are located in United States.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. As you head South, expect warmer temperatures. Make sure your car's AC is working well before embarking on this journey.

Coordinates come from public place data for Gainesville, Florida and Key West. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.