Fort Myers to Greenville, Mississippi: Road Trip Guide & Distance

How far is Fort Myers from Greenville, Mississippi?

The distance from Fort Myers to Greenville, Mississippi is 721 miles (1160.4 km) as the crow flies. Greenville, Mississippi is located NW of Fort Myers. By car, the driving distance is approximately 865.3 miles, taking about 17h 24min. A direct flight would take roughly 1h 57min. Both are located in United States — Fort Myers in Florida and Greenville, Mississippi in Mississippi.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Fort Myers and Greenville, Mississippi. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.