Florence, South Carolina to Sanford, Florida: Road Trip Guide & Distance

How far is Florence, South Carolina from Sanford, Florida?

The distance from Florence, South Carolina to Sanford, Florida is 383.2 miles (616.7 km) as the crow flies. Sanford, Florida is located SSW of Florence, South Carolina. By car, the driving distance is approximately 459.8 miles, taking about 9h 15min. A direct flight would take roughly 1h 16min. Both are located in United States — Florence, South Carolina in South Carolina and Sanford, Florida in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Florence, South Carolina and Sanford, Florida. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.