Florence, South Carolina to Knoxville: Road Trip Guide & Distance

How far is Florence, South Carolina from Knoxville?

The distance from Florence, South Carolina to Knoxville is 264.8 miles (426.2 km) as the crow flies. Knoxville is located WNW of Florence, South Carolina. By car, the driving distance is approximately 331.1 miles, taking about 6h 40min. A direct flight would take roughly 1h 2min. Both are located in United States — Florence, South Carolina in South Carolina and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Florence, South Carolina and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.