Florence, South Carolina to Huntsville, Alabama: Road Trip Guide & Distance

How far is Florence, South Carolina from Huntsville, Alabama?

The distance from Florence, South Carolina to Huntsville, Alabama is 390.4 miles (628.3 km) as the crow flies. Huntsville, Alabama is located W of Florence, South Carolina. By car, the driving distance is approximately 468.5 miles, taking about 9h 26min. A direct flight would take roughly 1h 17min. Both are located in United States — Florence, South Carolina in South Carolina and Huntsville, Alabama in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Florence, South Carolina and Huntsville, Alabama. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.