Florence, South Carolina to Harrisonburg: Road Trip Guide & Distance

How far is Florence, South Carolina from Harrisonburg?

The distance from Florence, South Carolina to Harrisonburg is 298.1 miles (479.8 km) as the crow flies. Harrisonburg is located N of Florence, South Carolina. By car, the driving distance is approximately 372.7 miles, taking about 7h 30min. A direct flight would take roughly 1h 6min. Both are located in United States — Florence, South Carolina in South Carolina and Harrisonburg in Virginia.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time.

Coordinates come from public place data for Florence, South Carolina and Harrisonburg. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.