Florence, South Carolina to Germantown, Maryland: Road Trip Guide & Distance

How far is Florence, South Carolina from Germantown, Maryland?

The distance from Florence, South Carolina to Germantown, Maryland is 370.5 miles (596.3 km) as the crow flies. Germantown, Maryland is located NNE of Florence, South Carolina. By car, the driving distance is approximately 444.7 miles, taking about 8h 57min. A direct flight would take roughly 1h 15min. Both are located in United States — Florence, South Carolina in South Carolina and Germantown, Maryland in Maryland.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Florence, South Carolina and Germantown, Maryland. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.