Florence, Alabama to Knoxville: Road Trip Guide & Distance

How far is Florence, Alabama from Knoxville?

The distance from Florence, Alabama to Knoxville is 226.3 miles (364.2 km) as the crow flies. Knoxville is located ENE of Florence, Alabama. By car, the driving distance is approximately 282.9 miles, taking about 5h 41min. A direct flight would take roughly 57min. Both are located in United States — Florence, Alabama in Alabama and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Florence, Alabama and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.