Durham, North Carolina to Gainesville, Florida: Road Trip Guide & Distance

How far is Durham, North Carolina from Gainesville, Florida?

The distance from Durham, North Carolina to Gainesville, Florida is 481.2 miles (774.4 km) as the crow flies. Gainesville, Florida is located SSW of Durham, North Carolina. By car, the driving distance is approximately 577.4 miles, taking about 11h 37min. A direct flight would take roughly 1h 28min. Both are located in United States — Durham, North Carolina in North Carolina and Gainesville, Florida in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Durham, North Carolina and Gainesville, Florida. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.