Dubuque to O'Fallon, Missouri: Road Trip Guide & Distance

How far is Dubuque from O'Fallon, Missouri?

The distance from Dubuque to O'Fallon, Missouri is 254.9 miles (410.3 km) as the crow flies. O'Fallon, Missouri is located S of Dubuque. By car, the driving distance is approximately 318.7 miles, taking about 6h 25min. A direct flight would take roughly 1h 1min. Both are located in United States — Dubuque in Iowa and O'Fallon, Missouri in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee.

Coordinates come from public place data for Dubuque and O'Fallon, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.