Dothan to Opelousas: Road Trip Guide & Distance

How far is Dothan from Opelousas?

The distance from Dothan to Opelousas is 399.5 miles (643 km) as the crow flies. Opelousas is located W of Dothan. By car, the driving distance is approximately 479.4 miles, taking about 9h 39min. A direct flight would take roughly 1h 18min. Both are located in United States — Dothan in Alabama and Opelousas in Louisiana.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Dothan and Opelousas. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.