Des Plaines to Kirksville: Road Trip Guide & Distance

How far is Des Plaines from Kirksville?

The distance from Des Plaines to Kirksville is 275.6 miles (443.6 km) as the crow flies. Kirksville is located WSW of Des Plaines. By car, the driving distance is approximately 344.6 miles, taking about 6h 56min. A direct flight would take roughly 1h 3min. Both are located in United States — Des Plaines in Illinois and Kirksville in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Des Plaines and Kirksville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.