Des Moines to Santa Fe: Road Trip Guide & Distance

How far is Des Moines from Santa Fe?

The distance from Des Moines to Santa Fe is 778.5 miles (1252.8 km) as the crow flies. Santa Fe is located WSW of Des Moines. By car, the driving distance is approximately 934.2 miles, taking about 18h 48min. A direct flight would take roughly 2h 4min. Both are located in United States — Des Moines in Iowa and Santa Fe in New Mexico.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Des Moines and Santa Fe. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.