Daytona Beach to Florence, South Carolina: Road Trip Guide & Distance

How far is Daytona Beach from Florence, South Carolina?

The distance from Daytona Beach to Florence, South Carolina is 352.3 miles (566.9 km) as the crow flies. Florence, South Carolina is located NNE of Daytona Beach. By car, the driving distance is approximately 422.7 miles, taking about 8h 30min. A direct flight would take roughly 1h 13min. Both are located in United States — Daytona Beach in Florida and Florence, South Carolina in South Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Daytona Beach and Florence, South Carolina. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.