Cuyahoga Valley to Knoxville: Road Trip Guide & Distance

How far is Cuyahoga Valley from Knoxville?

The distance from Cuyahoga Valley to Knoxville is 388.9 miles (625.8 km) as the crow flies. Knoxville is located SSW of Cuyahoga Valley. By car, the driving distance is approximately 466.6 miles, taking about 9h 23min. A direct flight would take roughly 1h 17min. Both are located in United States — Cuyahoga Valley in Ohio and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cuyahoga Valley and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.