Columbia, Missouri to La Crosse: Road Trip Guide & Distance

How far is Columbia, Missouri from La Crosse?

The distance from Columbia, Missouri to La Crosse is 339.8 miles (546.9 km) as the crow flies. La Crosse is located N of Columbia, Missouri. By car, the driving distance is approximately 407.8 miles, taking about 8h 12min. A direct flight would take roughly 1h 11min. Both are located in United States — Columbia, Missouri in Missouri and La Crosse in Wisconsin.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading North for this distance usually means noticeable weather changes. Make sure to check the forecast for your destination before hitting the road.

Coordinates come from public place data for Columbia, Missouri and La Crosse. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.