Columbia, Missouri to Florence, Alabama: Road Trip Guide & Distance

How far is Columbia, Missouri from Florence, Alabama?

The distance from Columbia, Missouri to Florence, Alabama is 385.3 miles (620.1 km) as the crow flies. Florence, Alabama is located SE of Columbia, Missouri. By car, the driving distance is approximately 462.4 miles, taking about 9h 18min. A direct flight would take roughly 1h 17min. Both are located in United States — Columbia, Missouri in Missouri and Florence, Alabama in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Columbia, Missouri and Florence, Alabama. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.