Clarksville to Greenville, South Carolina: Road Trip Guide & Distance

How far is Clarksville from Greenville, South Carolina?

The distance from Clarksville to Greenville, South Carolina is 301.7 miles (485.6 km) as the crow flies. Greenville, South Carolina is located ESE of Clarksville. By car, the driving distance is approximately 377.2 miles, taking about 7h 35min. A direct flight would take roughly 1h 6min. Both are located in United States — Clarksville in Tennessee and Greenville, South Carolina in South Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Clarksville and Greenville, South Carolina. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.