Clarksdale to Kirksville: Road Trip Guide & Distance

How far is Clarksdale from Kirksville?

The distance from Clarksdale to Kirksville is 428.7 miles (689.9 km) as the crow flies. Kirksville is located NNW of Clarksdale. By car, the driving distance is approximately 514.4 miles, taking about 10h 21min. A direct flight would take roughly 1h 22min. Both are located in United States — Clarksdale in Mississippi and Kirksville in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Clarksdale and Kirksville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.