Clarksdale to Enterprise: Road Trip Guide & Distance

How far is Clarksdale from Enterprise?

The distance from Clarksdale to Enterprise is 338.8 miles (545.2 km) as the crow flies. Enterprise is located SE of Clarksdale. By car, the driving distance is approximately 406.5 miles, taking about 8h 11min. A direct flight would take roughly 1h 11min. Both are located in United States — Clarksdale in Mississippi and Enterprise in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Clarksdale and Enterprise. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.