Cincinnati to Knoxville: Road Trip Guide & Distance

How far is Cincinnati from Knoxville?

The distance from Cincinnati to Knoxville is 219.5 miles (353.3 km) as the crow flies. Knoxville is located S of Cincinnati. By car, the driving distance is approximately 274.4 miles, taking about 5h 31min. A direct flight would take roughly 56min. Both are located in United States — Cincinnati in Ohio and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee.

Coordinates come from public place data for Cincinnati and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.