Cincinnati to Florence, South Carolina: Road Trip Guide & Distance

How far is Cincinnati from Florence, South Carolina?

The distance from Cincinnati to Florence, South Carolina is 429.2 miles (690.7 km) as the crow flies. Florence, South Carolina is located SE of Cincinnati. By car, the driving distance is approximately 515 miles, taking about 10h 22min. A direct flight would take roughly 1h 22min. Both are located in United States — Cincinnati in Ohio and Florence, South Carolina in South Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cincinnati and Florence, South Carolina. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.