Cincinnati to Durham, North Carolina: Road Trip Guide & Distance

How far is Cincinnati from Durham, North Carolina?

The distance from Cincinnati to Durham, North Carolina is 375 miles (603.5 km) as the crow flies. Durham, North Carolina is located ESE of Cincinnati. By car, the driving distance is approximately 450 miles, taking about 9h 3min. A direct flight would take roughly 1h 15min. Both are located in United States — Cincinnati in Ohio and Durham, North Carolina in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cincinnati and Durham, North Carolina. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.