Chillicothe to Knoxville: Road Trip Guide & Distance

How far is Chillicothe from Knoxville?

The distance from Chillicothe to Knoxville is 238.6 miles (384 km) as the crow flies. Knoxville is located SSW of Chillicothe. By car, the driving distance is approximately 298.3 miles, taking about 6h 0min. A direct flight would take roughly 59min. Both are located in United States — Chillicothe in Ohio and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Chillicothe and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.