Chillicothe to Columbia, Missouri: Road Trip Guide & Distance

How far is Chillicothe from Columbia, Missouri?

The distance from Chillicothe to Columbia, Missouri is 501.6 miles (807.2 km) as the crow flies. Columbia, Missouri is located W of Chillicothe. By car, the driving distance is approximately 601.9 miles, taking about 12h 6min. A direct flight would take roughly 1h 31min. Both are located in United States — Chillicothe in Ohio and Columbia, Missouri in Missouri.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Chillicothe and Columbia, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.