Cheyenne to Sioux Falls: Road Trip Guide & Distance

How far is Cheyenne from Sioux Falls?

The distance from Cheyenne to Sioux Falls is 445.2 miles (716.4 km) as the crow flies. Sioux Falls is located ENE of Cheyenne. By car, the driving distance is approximately 534.2 miles, taking about 10h 45min. A direct flight would take roughly 1h 24min. Both are located in United States — Cheyenne in Wyoming and Sioux Falls in South Dakota.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cheyenne and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.