Charlottesville to Greenville, South Carolina: Road Trip Guide & Distance

How far is Charlottesville from Greenville, South Carolina?

The distance from Charlottesville to Greenville, South Carolina is 309.1 miles (497.5 km) as the crow flies. Greenville, South Carolina is located SW of Charlottesville. By car, the driving distance is approximately 386.4 miles, taking about 7h 46min. A direct flight would take roughly 1h 7min. Both are located in United States — Charlottesville in Virginia and Greenville, South Carolina in South Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Charlottesville and Greenville, South Carolina. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.