Charleston, South Carolina to Fort Myers: Road Trip Guide & Distance

How far is Charleston, South Carolina from Fort Myers?

The distance from Charleston, South Carolina to Fort Myers is 439.6 miles (707.5 km) as the crow flies. Fort Myers is located SSW of Charleston, South Carolina. By car, the driving distance is approximately 527.5 miles, taking about 10h 37min. A direct flight would take roughly 1h 23min. Both are located in United States — Charleston, South Carolina in South Carolina and Fort Myers in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Charleston, South Carolina and Fort Myers. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.