Charleston, Illinois to Greenville, Mississippi: Road Trip Guide & Distance

How far is Charleston, Illinois from Greenville, Mississippi?

The distance from Charleston, Illinois to Greenville, Mississippi is 450 miles (724.2 km) as the crow flies. Greenville, Mississippi is located SSW of Charleston, Illinois. By car, the driving distance is approximately 540 miles, taking about 10h 52min. A direct flight would take roughly 1h 24min. Both are located in United States — Charleston, Illinois in Illinois and Greenville, Mississippi in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Charleston, Illinois and Greenville, Mississippi. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.