Cape Girardeau to Winston-Salem: Road Trip Guide & Distance
How far is Cape Girardeau from Winston-Salem?
The distance from Cape Girardeau to Winston-Salem is 520.2 miles (837.2 km) as the crow flies. Winston-Salem is located E of Cape Girardeau. By car, the driving distance is approximately 624.2 miles, taking about 12h 33min. A direct flight would take roughly 1h 33min. Both are located in United States — Cape Girardeau in Missouri and Winston-Salem in North Carolina.
This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.
Coordinates come from public place data for Cape Girardeau and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.
How to Get from Cape Girardeau to Winston-Salem
Suggested Stops Between Cape Girardeau & Winston-Salem
- 1402 mi
- 2171 mi
- 3388 mi
- 4116 mi
- 5352 mi
Quick Facts
Did You Know?
- At walking speed (3 mph), it would take about 173 hours of non-stop walking
- By bicycle at 12 mph, the journey would take roughly 43 hours
- You could travel this distance about 47.9 times to circle the Earth's equator