Cape Girardeau to Tuscaloosa: Road Trip Guide & Distance

How far is Cape Girardeau from Tuscaloosa?

The distance from Cape Girardeau to Tuscaloosa is 303.6 miles (488.6 km) as the crow flies. Tuscaloosa is located SSE of Cape Girardeau. By car, the driving distance is approximately 379.5 miles, taking about 7h 38min. A direct flight would take roughly 1h 7min. Both are located in United States — Cape Girardeau in Missouri and Tuscaloosa in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Tuscaloosa. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.