Cape Girardeau to Seymour: Road Trip Guide & Distance

How far is Cape Girardeau from Seymour?

The distance from Cape Girardeau to Seymour is 227.9 miles (366.7 km) as the crow flies. Seymour is located ENE of Cape Girardeau. By car, the driving distance is approximately 284.8 miles, taking about 5h 44min. A direct flight would take roughly 58min. Both are located in United States — Cape Girardeau in Missouri and Seymour in Indiana.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Seymour. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.