Cape Girardeau to Ruston: Road Trip Guide & Distance

How far is Cape Girardeau from Ruston?

The distance from Cape Girardeau to Ruston is 374.7 miles (603 km) as the crow flies. Ruston is located SSW of Cape Girardeau. By car, the driving distance is approximately 449.6 miles, taking about 9h 3min. A direct flight would take roughly 1h 15min. Both are located in United States — Cape Girardeau in Missouri and Ruston in Louisiana.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cape Girardeau and Ruston. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.